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Article

Interactome evolution: insights from genome-wide analyses of protein-protein interactions.

Current opinion in structural biology - 1 Jun 2018

Ghadie Mohamed A, Coulombe-Huntington Jasmin, Xia Yu

Abstract excerpt

We highlight new evolutionary insights enabled by recent genome-wide studies on protein-protein interaction (PPI) networks ('interactomes'). While most PPIs are mediated by a single sequence region promoting or inhibiting interactions, many PPIs are mediated by multiple sequence regions acting cooperatively. Most PPIs perform important functions maintained by negative selection: we estimate that less than ∼10% of...

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Identifiers

PMID: 29112911
DOI: 10.1016/j.sbi.2017.10.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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