Article

SENSE-PPI reconstructs protein-protein interactions of various complexities, within, across, and between species, with sequence-based evolutionary scale modeling and deep learning

2023-09-21

Abstract excerpt

Ab initio computational reconstructions of protein-protein interaction (PPI) networks will provide invaluable insights on cellular systems, enabling the discovery of novel molecular interactions and elucidating biological mechanisms within and between organisms. Leveraging latest generation protein language models and recurrent neural networks, we present SENSE-PPI , a sequence-based deep learning model that effi...

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Literature Corpus work: 5e4cfd1e-7dbd-5bbc-b04c-d1fd127a9532
DOI: 10.1101/2023.09.19.558413

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