Article

Prediction and discovery of protein-protein direct interactions and stable complexes based on gene co-expression and co-evolution

2024-10-06

Abstract excerpt

In this study we employed a data-driven approach to explore the evolutionary and genetic determinants of protein direct interactions and stable complex formation in the human proteome. We found that simple co-evolutionary and co-expression metrics are highly informative of direct interactions and stable complexes. We used this information to train supervised binary classifiers to predict interactions either direct...

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Literature Corpus work: 999b4596-76d3-5e7a-9f33-a566f4ba7150
DOI: 10.1101/2024.10.05.616780

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