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TGFBR2 <sup>High</sup> mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell function

2025-01-08

Abstract excerpt

Attempts to activate an anti-tumor immune response in glioblastoma (GBM) have been met with many challenges due to its inherently immunosuppressive tumor microenvironment. The degree and mechanisms by which molecularly and phenotypically diverse tumor-propagating glioma stem cells (GSCs) contribute to this state are poorly defined. In this study, our multifaceted approach combining bioinformatics analyses of clini...

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Literature Corpus work
e0aa8a41-1a18-5160-b286-85397e6b1b5f
DOI
10.1101/2025.01.07.631757
Open publication

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TGFBR2 <sup>High</sup> mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell functionDOI 10.1101/2025.01.07.631757
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