Article

Integrated spatial and single-cell transcriptomic analysis of aggressive glioblastoma growth dynamics

2026-05-14

Abstract excerpt

Glioblastoma (GBM) develops within a complex tumor ecosystem whose temporal dynamics remain poorly understood. Here, we performed longitudinal single-cell RNA sequencing and spatial transcriptomics across multiple timepoints in two widely used murine GBM models - CT2A and GL261 - which differ markedly in aggressiveness and response to immune checkpoint blockade. Tumor cell transcriptomes revealed model-specific pr...

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Literature Corpus work: 1b0f2f00-5299-5f9d-a700-ca3d0bc1c073
DOI: 10.64898/2026.05.11.724432

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