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Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunities

21 Sept 2022

Abstract excerpt

Despite its growing use in cancer treatment, immunotherapy has been virtually ineffective in clinical trials for gliomas. The inherently cold tumor immune microenvironment (TIME) in gliomas, characterized by a high ratio of pro-tumor to anti-tumor immune cell infiltrates, acts as a seemingly insurmountable barrier to immunotherapy. Glioma stem cells (GSCs) within these tumors are key contributors to this cold...

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PMID: 36212415
DOI: 10.3389/fonc.2022.995498

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