Article

Dual checkpoint blockade of glioblastoma with Anti-PD-1 and Anti-LAG-3 promotes expansion of tumor-reactive T cell clones along a unique pathway of differentiation

2025-09-11

Abstract excerpt

<h4>ABSTRACT</h4> IDH-wildtype grade IV glioblastoma is the most aggressive adult primary brain tumor and remains refractory to anti-PD-1 monotherapy despite evidence of limited tumor-specific T cell induction. To determine the impact of immune checkpoint inhibitors (ICIs) on glioblastoma T cell transcriptional landscape and repertoire, we conducted paired single-cell RNA sequencing (scRNA-seq) and T cell recepto...

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Literature Corpus work: 94e63fc2-5dcd-56f8-a81b-cb801b896fd0
DOI: 10.1101/2025.09.06.674490

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