Article

TGFBR2High Mesenchymal Glioma Stem Cells Phenocopy Regulatory T Cells to Suppress CD4+ and CD8+ T Cell Function

2025-01-12

Abstract excerpt

Attempts to activate an anti-tumor immune response in glioblastoma (GBM) have been met with many challenges due to its inherently immunosuppressive tumor microenvironment. The degree and mechanisms by which molecularly and phenotypically diverse tumor-propagating glioma stem cells (GSCs) contribute to this state are poorly defined. In this study, our multifaceted approach combining bioinformatics analyses of clini...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93b18785-f75d-5bee-9626-0582f9e7a91e
DOI: 10.32388/70p2ux

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TGFBR2High Mesenchymal Glioma Stem Cells Phenocopy Regulatory T Cells to Suppress CD4+ and CD8+ T Cell FunctionDOI 10.32388/70p2uxRead

TGFBR2 <sup>High</sup> mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell functionSemantic proximity Read

Integrated spatial and single-cell transcriptomic analysis of aggressive glioblastoma growth dynamicsSemantic proximity Read

Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunitiesSemantic proximity Read

Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated MacrophagesSemantic proximity Read

A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical ModelsSemantic proximity Read

Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signalingSemantic proximity Read

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in GliomaSemantic proximity Read

B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated ImmunosuppressionSemantic proximity Read

Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14Semantic proximity Read

MiR-10b-5p Impairs TET2-Mediated Inhibition of PD-L1 Transcription Thus Promoting Immune Evasion and Tumor Progression in GlioblastomaSemantic proximity Read

Cancer Stem Cells and Immunosuppressive Microenvironment in GliomaSemantic proximity Read

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironmentSemantic proximity Read