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Multigenerational downregulation of insulin/IGF-1 signalling in adulthood improves lineage survival, reproduction, and fitness in <i>C. elegans</i> supporting the developmental theory of ageing

2020-08-19

Abstract excerpt

Adulthood-only downregulation of insulin/IGF-1 signalling (IIS), an evolutionarily conserved pathway regulating resource allocation between somatic maintenance and reproduction, increases lifespan without fecundity cost in the nematode, Caenorhabditis elegans . However, long-term multigenerational effects of reduced IIS remain unexplored and are proposed to carry costs for offspring quality. To test this hypothes...

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Literature Corpus work
e0aa80f8-6a61-5e57-a693-ce2f8aec0671
DOI
10.1101/2020.08.19.257253
Open publication

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Multigenerational downregulation of insulin/IGF-1 signalling in adulthood improves lineage survival, reproduction, and fitness in <i>C. elegans</i> supporting the developmental theory of ageingDOI 10.1101/2020.08.19.257253
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