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Article

Fitness cost of extended lifespan in Caenorhabditis elegans.

Proceedings. Biological sciences - 7 Dec 2004

Jenkins Nicole L, McColl Gawain, Lithgow Gordon J

Abstract excerpt

An insulin/IGF-I-like signalling pathway determines the rate of aging of the adult nematode, Caenorhabditis elegans. Mutations in genes encoding this pathway can result in a doubling of lifespan. While such mutations may appear to have little effect on development or fertility, evolutionary theory predicts that large increases in lifespan will not be optimal for fitness. We demonstrate by laboratory natural...

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Identifiers

PMID: 15590605
DOI: 10.1098/rspb.2004.2897
PMCID: PMC1440519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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