Article

Cost-free lifespan extension via optimisation of gene expression in adulthood supports the developmental theory of ageing

2019-08-20

Abstract excerpt

<h4>Summary</h4> Classic theory upholds that energy trade-offs between reproduction and somatic maintenance underpin the evolution of ageing and lifespan. In contrast, the developmental theory of ageing (DTA) suggests that organismal senescence is caused by dysregulated gene expression in adulthood due to decline in selection gradients with age. The DTA predicts that age-specific optimisation of gene expression c...

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Literature Corpus work: a6b391e4-b026-57f9-9725-b98017d96cdd
DOI: 10.1101/739490

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