Article

Lifespan-extending downregulation of insulin signalling reduces germline mutation load

2025-12-05

Abstract excerpt

Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine multigenerational mutation accumulation with whole-genome sequencing in C. elegans to test whether adulthood-only IIS downregulation can simultaneously promote somatic maintenance and limit germline mutational burden...

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Literature Corpus work: 2bef5f03-163f-5a10-8215-dd9c73b8d1fb
DOI: 10.64898/2025.12.05.692572

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