Article

Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

2018-02-13

Abstract excerpt

<h4>ABSTRACT</h4> We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference were used in an integrated manner to down-regulate protein expression. Developmentally timed transcriptional interference inhibited production of a well translated mRNA isoform and resulted in the production of an mRNA isoform containing inhibitory upstream ope...

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Literature Corpus work: e083f704-c5fc-5482-9bf3-447944a69905
DOI: 10.1101/264721

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