Article

Conserved sequence elements in the final exon of MDM2-eight-exon skipping event reveal a ‘cassette regulon’ model of alternative splicing controlled by a distal regulatory element

2026-02-17

Abstract excerpt

Modern sequencing technologies have revealed that cancers exhibit widespread dysregulation of alternative splicing, which plays a significant role in driving tumor hallmarks. Alternative splicing enables a single gene to generate multiple mRNA variants, a fundamental mechanism that shapes the distinctive characteristics of normal cells as well as cancer cells. These splicing events are governed by complex interact...

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Literature Corpus work: 14d0a70f-588e-5e1a-8dd0-4ca9f3bd7ee6
DOI: 10.64898/2026.02.14.705925

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