Article

Human prefoldin modulates co-transcriptional pre-mRNA splicing

2020-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, including a positive contribution to transcription elongation and chromatin dynamics in yeast. Here we show that prefoldin perturbations provoked transcriptional alterations...

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Literature Corpus work: 74ed8bf3-10ee-5302-86c6-2b94ba303d9a
DOI: 10.1101/2020.06.14.150466

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