Article

Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control

2025-01-08

Abstract excerpt

The translation of mRNA into proteins in multicellular organisms needs to be carefully tuned to changing proteome demands in development and differentiation, and defects in translation often have a disproportionate impact in distinct cell types. Here we used inducible CRISPR interference screens to compare the essentiality of genes with functions in mRNA translation in human induced pluripotent stem cells (hiPSC)...

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Identifiers and source

Literature Corpus work: aa6b490a-8878-5cf3-8163-091f9234ac95
DOI: 10.1101/2025.01.07.631643

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