Article

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA Decay

2024-12-28

Abstract excerpt

<h4>ABSTRACT</h4> Pre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm called nonsense mediated mRNA decay (NMD). The NMD pathway monitors for premature translation termination signals, which can result from alternative splicing, by relying on the exon junction complex (...

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Literature Corpus work: 3092c17a-6f0f-5761-a65d-f50f8b23669c
DOI: 10.1101/2024.12.27.630533

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