Article

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

2019-12-16

Abstract excerpt

The accumulation of amyloid Tau aggregates is implicated in Alzheimer’s disease and other Tauopathies. Molecular chaperones are known for their function in maintaining protein homeostasis by preventing the formation or promoting the disaggregation of amorphous and amyloid protein aggregates. Here we show that an ATP-dependent human chaperone system disassembles Tau fibrils in vitro . This function is mediated by...

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Literature Corpus work: e03d015b-e30c-5bc0-b533-bbf228440708
DOI: 10.1101/2019.12.16.876888

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