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Article

Disaggregating chaperones: an unfolding story.

Current protein & peptide science - 1 Oct 2009

Sharma Sandeep K, Christen Philipp, Goloubinoff Pierre

Abstract excerpt

Stress, molecular crowding and mutations may jeopardize the native folding of proteins. Misfolded and aggregated proteins not only loose their biological activity, but may also disturb protein homeostasis, damage membranes and induce apoptosis. Here, we review the role of molecular chaperones as a network of cellular defenses against the formation of cytotoxic protein aggregates. Chaperones favour the native...

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Identifiers

PMID: 19538153
DOI: 10.2174/138920309789351930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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