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Article

Clearance of variant Creutzfeldt–Jakob disease prions in vivo by the Hsp70 disaggregase system

20 Apr 2022

Abstract excerpt

The metazoan Hsp70 disaggregase protects neurons from proteotoxicity that arises from the accumulation of misfolded protein aggregates. Hsp70 and its co-chaperones disassemble and extract polypeptides from protein aggregates for refolding or degradation. The effectiveness of the chaperone system decreases with age and leads to accumulation rather than removal of neurotoxic protein aggregates. Therapeutic...

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PMID: 35446941
DOI: 10.1093/brain/awac144

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