Article
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
The Journal of biological chemistry - 22 May 2015
Fontaine Sarah N, Rauch Jennifer N, Nordhues Bryce A, Assimon Victoria A, Stothert Andrew R, Jinwal Umesh K, Sabbagh Jonathan J, Chang Lyra, Stevens Stanley M, Zuiderweg Erik R P, Gestwicki Jason E, Dickey Chad A
Abstract excerpt
The constitutively expressed heat shock protein 70 kDa (Hsc70) is a major chaperone protein responsible for maintaining proteostasis, yet how its structure translates into functional decisions regarding client fate is still unclear. We previously showed that Hsc70 preserved aberrant Tau, but it remained unknown if selective inhibition of the activity of this Hsp70 isoform could facilitate Tau clearance. Using...
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