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Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention

1 Jan 2013

Abstract excerpt

Maintenance of cellular homeostasis is regulated by the molecular chaperones. Under pathogenic conditions, aberrant proteins are triaged by the chaperone network. These aberrant proteins, known as "clients," have major roles in the pathogenesis of numerous neurological disorders, including tau in Alzheimer's disease, α-synuclein and LRRK2 in Parkinson's disease, SOD-1, TDP-43 and FUS in amyotrophic lateral...

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PMID: 25258700
DOI: 10.4172/2161-0460.s10-007

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