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Article

Hsp110 mitigates α-synuclein pathology in vivo

4 Nov 2019

Abstract excerpt

Parkinson's disease is characterized by the aggregation of the presynaptic protein α-synuclein and its deposition into pathologic Lewy bodies. While extensive research has been carried out on mediators of α-synuclein aggregation, molecular facilitators of α-synuclein disaggregation are still generally unknown. We investigated the role of molecular chaperones in both preventing and disaggregating α-synuclein...

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PMID: 31685606
DOI: 10.1073/pnas.1903268116

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