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Article

Hsp40s play complementary roles in the prevention of tau amyloid formation.

eLife - 9 Aug 2021

Irwin Rose, Faust Ofrah, Petrovic Ivana, Wolf Sharon Grayer, Hofmann Hagen, Rosenzweig Rina

Abstract excerpt

The microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as Alzheimer's disease. In the cell, however, tau aggregation can be prevented by a class of proteins known as molecular chaperones. While numerous chaperones are known to interact with tau, though, little is known regarding the mechanisms by which these prevent tau...

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Share to Amyloidogenic Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34369377
DOI: 10.7554/eLife.69601
PMCID: PMC8437434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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