Article

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

2019-10-09

Abstract excerpt

<h4>ABSTRACT</h4> The gradual accumulation and prion-like propagation of α-synuclein and other amyloidogenic proteins is associated with devastating neurodegenerative diseases. The metazoan disaggregation machinery, a specific combination of HSP70 and its co-chaperones, is able to disassemble α-synuclein fibrils in vitro , but the physiological consequence in vivo is unknown. To explore this, we used Caenorhab...

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Literature Corpus work: 5b5cfd60-b5c0-5fc4-9d4e-0fcec8a8cd7b
DOI: 10.1101/795435

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