Article

Large-scale genome- and phenome-wide analyses reveal the genetic architecture, pathophysiology and comorbidity of restless legs syndrome

2026-05-22

Abstract excerpt

Restless legs syndrome (RLS) is a common sleep-related movement disorder, affecting approximately 4% of adults worldwide, with a substantially higher prevalence in individuals of European ancestry, reaching 5-13%. However, its genetic architecture and pathophysiology remain poorly understood. Here, we conducted a large-scale meta-analysis of more than 1.3 million individuals of European ancestry to explored the sh...

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Literature Corpus work: e01c8939-d12f-5713-99a5-955f6d18c671
DOI: 10.64898/2026.05.21.26353752

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