Article
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
Nature genetics - 1 Jun 2024
Schormair Barbara, Zhao Chen, Bell Steven, Didriksen Maria, Nawaz Muhammad S, Schandra Nathalie, Stefani Ambra, Högl Birgit, Dauvilliers Yves, Bachmann Cornelius G, Kemlink David, Sonka Karel, Paulus Walter, Trenkwalder Claudia, Oertel Wolfgang H, Hornyak Magdolna, Teder-Laving Maris, Metspalu Andres, Hadjigeorgiou Georgios M, Polo Olli, Fietze Ingo, Ross Owen A, Wszolek Zbigniew K, Ibrahim Abubaker, Bergmann Melanie, Kittke Volker, Harrer Philip, Dowsett Joseph, Chenini Sofiene, Ostrowski Sisse Rye, Sørensen Erik, Erikstrup Christian, Pedersen Ole B, Topholm Bruun Mie, Nielsen Kaspar R, Butterworth Adam S, Soranzo Nicole, Ouwehand Willem H, Roberts David J, Danesh John, Burchell Brendan, Furlotte Nicholas A, Nandakumar Priyanka, Earley Christopher J, Ondo William G, Xiong Lan, Desautels Alex, Perola Markus, Vodicka Pavel, Dina Christian, Stoll Monika, Franke Andre, Lieb Wolfgang, Stewart Alexandre F R, Shah Svati H, Gieger Christian, Peters Annette, Rye David B, Rouleau Guy A, Berger Klaus, Stefansson Hreinn, Ullum Henrik, Stefansson Kari, Hinds David A, Di Angelantonio Emanuele, Oexle Konrad, Winkelmann Juliane
Abstract excerpt
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci...
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