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Article

Genetics of restless legs syndrome.

Current neurology and neuroscience reports - 1 May 2008

Winkelmann Juliane

Abstract excerpt

Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%. It is a polygenetic disorder in which a number of variants contribute to the phenotype. Linkage studies in families with RLS revealed several loci but have not yet led to the identification of disease-causing sequence variants. Phenocopies, nonpenetrance, and possible intrafamilial heterogeneity make it difficult to...

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Source

Identifiers

PMID: 18541116
DOI: 10.1007/s11910-008-0033-y

Genes

MEIS1
BTBD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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