Article
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
The Lancet. Neurology - 1 Nov 2017
Schormair Barbara, Zhao Chen, Bell Steven, Tilch Erik, Salminen Aaro V, Pütz Benno, Dauvilliers Yves, Stefani Ambra, Högl Birgit, Poewe Werner, Kemlink David, Sonka Karel, Bachmann Cornelius G, Paulus Walter, Trenkwalder Claudia, Oertel Wolfgang H, Hornyak Magdolna, Teder-Laving Maris, Metspalu Andres, Hadjigeorgiou Georgios M, Polo Olli, Fietze Ingo, Ross Owen A, Wszolek Zbigniew, Butterworth Adam S, Soranzo Nicole, Ouwehand Willem H, Roberts David J, Danesh John, Allen Richard P, Earley Christopher J, Ondo William G, Xiong Lan, Montplaisir Jacques, Gan-Or Ziv, Perola Markus, Vodicka Pavel, Dina Christian, Franke Andre, Tittmann Lukas, Stewart Alexandre F R, Shah Svati H, Gieger Christian, Peters Annette, Rouleau Guy A, Berger Klaus, Oexle Konrad, Di Angelantonio Emanuele, Hinds David A, Müller-Myhsok Bertram, Winkelmann Juliane
Abstract excerpt
BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. METHODS: In the discovery stage, we combined three GWAS datasets...
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