Article
Large genome-wide association study identifies three novel risk variants for restless legs syndrome.
Communications biology - 25 Nov 2020
Didriksen Maria, Nawaz Muhammad Sulaman, Dowsett Joseph, Bell Steven, Erikstrup Christian, Pedersen Ole B, Sørensen Erik, Jennum Poul J, Burgdorf Kristoffer S, Burchell Brendan, Butterworth Adam S, Soranzo Nicole, Rye David B, Trotti Lynn Marie, Saini Prabhjyot, Stefansdottir Lilja, Magnusson Sigurdur H, Thorleifsson Gudmar, Sigmundsson Thordur, Sigurdsson Albert P, Van Den Hurk Katja, Quee Franke, Tanck Michael W T, Ouwehand Willem H, Roberts David J, Earley Eric J, Busch Michael P, Mast Alan E, Page Grier P, Danesh John, Di Angelantonio Emanuele, Stefansson Hreinn, Ullum Henrik, Stefansson Kari
Abstract excerpt
Restless legs syndrome (RLS) is a common neurological sensorimotor disorder often described as an unpleasant sensation associated with an urge to move the legs. Here we report findings from a meta-analysis of genome-wide association studies of RLS including 480,982 Caucasians (cases = 10,257) and a follow up sample of 24,977 (cases = 6,651). We confirm 19 of the 20 previously reported RLS sequence variants at 19...
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