Article
Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.
American journal of human genetics - 1 May 2004
Chen Shenghan, Ondo William G, Rao Shaoqi, Li Lin, Chen Qiuyun, Wang Qing
Abstract excerpt
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%-12% of all whites. To genetically dissect this complex disease, we characterized 15 large and extended multiplex pedigrees, consisting of 453 subjects (134 affected with RLS). A familial aggregation analysis was performed, and SAGE FCOR was used to quantify the total genetic contribution in these families. A weighted average...
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