Article
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
PLoS genetics - 1 Jul 2011
Winkelmann Juliane, Czamara Darina, Schormair Barbara, Knauf Franziska, Schulte Eva C, Trenkwalder Claudia, Dauvilliers Yves, Polo Olli, Högl Birgit, Berger Klaus, Fuhs Andrea, Gross Nadine, Stiasny-Kolster Karin, Oertel Wolfgang, Bachmann Cornelius G, Paulus Walter, Xiong Lan, Montplaisir Jacques, Rouleau Guy A, Fietze Ingo, Vávrová Jana, Kemlink David, Sonka Karel, Nevsimalova Sona, Lin Siong-Chi, Wszolek Zbigniew, Vilariño-Güell Carles, Farrer Matthew J, Gschliesser Viola, Frauscher Birgit, Falkenstetter Tina, Poewe Werner, Allen Richard P, Earley Christopher J, Ondo William G, Le Wei-Dong, Spieler Derek, Kaffe Maria, Zimprich Alexander, Kettunen Johannes, Perola Markus, Silander Kaisa, Cournu-Rebeix Isabelle, Francavilla Marcella, Fontenille Claire, Fontaine Bertrand, Vodicka Pavel, Prokisch Holger, Lichtner Peter, Peppard Paul, Faraco Juliette, Mignot Emmanuel, Gieger Christian, Illig Thomas, Wichmann H-Erich, Müller-Myhsok Bertram, Meitinger Thomas
Abstract excerpt
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that occurs mainly in resting situations during the evening or at night. Moving the legs or walking leads to an improvement of symptoms. Concomitantly, patients report...
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