Article
Gene expression elucidates functional impact of polygenic risk for schizophrenia.
Nature neuroscience - 1 Nov 2016
Fromer Menachem, Roussos Panos, Sieberts Solveig K, Johnson Jessica S, Kavanagh David H, Perumal Thanneer M, Ruderfer Douglas M, Oh Edwin C, Topol Aaron, Shah Hardik R, Klei Lambertus L, Kramer Robin, Pinto Dalila, Gümüş Zeynep H, Cicek A Ercument, Dang Kristen K, Browne Andrew, Lu Cong, Xie Lu, Readhead Ben, Stahl Eli A, Xiao Jianqiu, Parvizi Mahsa, Hamamsy Tymor, Fullard John F, Wang Ying-Chih, Mahajan Milind C, Derry Jonathan M J, Dudley Joel T, Hemby Scott E, Logsdon Benjamin A, Talbot Konrad, Raj Towfique, Bennett David A, De Jager Philip L, Zhu Jun, Zhang Bin, Sullivan Patrick F, Chess Andrew, Purcell Shaun M, Shinobu Leslie A, Mangravite Lara M, Toyoshiba Hiroyoshi, Gur Raquel E, Hahn Chang-Gyu, Lewis David A, Haroutunian Vahram, Peters Mette A, Lipska Barbara K, Buxbaum Joseph D, Schadt Eric E, Hirai Keisuke, Roeder Kathryn, Brennand Kristen J, Katsanis Nicholas, Domenici Enrico, Devlin Bernie, Sklar Pamela
Abstract excerpt
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ∼20% of schizophrenia loci have variants that could contribute...
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