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Article

Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia.

PLoS genetics - 1 Oct 2023

Radulescu Eugenia, Chen Qiang, Pergola Giulio, Di Carlo Pasquale, Han Shizhong, Shin Joo Heon, Hyde Thomas M, Kleinman Joel E, Weinberger Daniel R

Abstract excerpt

The effect of schizophrenia (SCZ) genetic risk on gene expression in brain remains elusive. A popular approach to this problem has been the application of gene co-expression network algorithms (e.g., WGCNA). To improve reliability with this method it is critical to remove unwanted sources of variance while also preserving biological signals of interest. In this WCGNA study of RNA-Seq data from postmortem...

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PMID: 37831723
DOI: 10.1371/journal.pgen.1010989
PMCID: PMC10599557

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