Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis

27 Jun 2024

Abstract excerpt

The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreatic islets during diabetes progression remains unclear. Here, we reanalyze the full-length single-cell RNA sequencing data from the deposited database to investigate AS regulation across human pancreatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Pancreatic function and diabetes
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38937540
DOI: 10.1038/s42003-024-06475-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesisPMID 38937540Read ↗

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specificSemantic proximity Read ↗

Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetesSemantic proximity Read ↗

Single Nucleus RNA Sequencing of Human Pancreatic Islets <i>In Vitro</i> and <i>In Vivo</i> Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional ProfileSemantic proximity Read ↗

Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-SequencingSemantic proximity Read ↗

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 DiabetesSemantic proximity Read ↗

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome.Semantic proximity Read ↗

Lessons from single-cell RNA sequencing of human isletsSemantic proximity Read ↗

Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human isletsSemantic proximity Read ↗

Single-Cell Transcriptomics of the Human Endocrine PancreasSemantic proximity Read ↗

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity Read ↗

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesSemantic proximity Read ↗

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profilesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.