Article

Differential impact of TNFRSF co-stimulation on CD8 <sup>+</sup> T cell cytokine production by feedback control of surface receptor expression

2021-07-03

Abstract excerpt

T cell responses towards infections and cancers are regulated by a host of co-signalling receptors that are largely grouped into the binary categories of co-stimulation and co-inhibition. The TNF receptor superfamily (TNFRSF) members 4-1BB, CD27, GITR, and OX40 are well-established co-stimulation receptors with largely shared molecular pathways raising the question of whether they also have a similar impact on qua...

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Literature Corpus work: dff25c8a-cdd2-54fa-b603-891d7dc685fb
DOI: 10.1101/2021.07.02.450833

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