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Combination antagonism of TNF superfamily signaling for T cell immunosuppression

2026-04-30

Abstract excerpt

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies comprise 47 proteins that regulate immune signaling and T cell costimulation. While TNF inhibitors are established therapies for immune-mediated inflammatory diseases (IMIDs), their efficacy is limited by primary non-response and loss of efficacy over time. Preclinical evidence suggests that TNF/TNFR members exhibit redundant and synergistic sig...

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Literature Corpus work
93added5-5eab-5ef4-af42-ff04ac715c2a
DOI
10.64898/2026.04.27.721101
Open publication

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Combination antagonism of TNF superfamily signaling for T cell immunosuppressionDOI 10.64898/2026.04.27.721101
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