Article

Beyond Antagonism: IL-4 Exploits TNF signaling to Shape Its Gene Expression Signature in Monocytes and Macrophages

2025-07-31

Abstract excerpt

Investigation of crosstalk between antagonistic pro- and anti-inflammatory cytokines has focused on mechanisms and functional consequences of cross-inhibition. We investigated cross-regulation between proinflammatory TNF and anti-inflammatory IL-4 in primary human monocytes and in a skin wound-healing model. Surprisingly, TNF functioned mainly as a costimulator of IL-4-induced gene expression, whereas IL-4 selecti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91a18922-25d1-5d73-b3ef-0c070cbdc4a1
DOI: 10.1101/2025.07.28.667180

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Beyond Antagonism: IL-4 Exploits TNF signaling to Shape Its Gene Expression Signature in Monocytes and MacrophagesDOI 10.1101/2025.07.28.667180Read

Combination antagonism of TNF superfamily signaling for T cell immunosuppressionSemantic proximity Read

Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ MacrophagesSemantic proximity Read

At the Crossroads of TNF α Signaling and CancerSemantic proximity Read

Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretomeSemantic proximity Read

CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblastsSemantic proximity Read

Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networksSemantic proximity Read

CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblastsSemantic proximity Read

Anti-TNF treatment corrects IFN-γ–dependent proinflammatory signatures in Blau syndrome patient–derived macrophagesSemantic proximity Read

IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic MechanismsSemantic proximity Read

Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1Semantic proximity Read

TNF biology, pathogenic mechanisms and emerging therapeutic strategiesSemantic proximity Read

Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17–Mediated Pathology and Signaling ProcessesSemantic proximity Read