Article

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

2021-06-08

Abstract excerpt

<title>Abstract</title> <p>While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Type 1 interferon (IFN-I) modulates T cell immunity in viral infection, autoimmunity, and cancer, and may facilitate induction of T cell exhaustion in chronic viral infection. Here we show that IFN-I regulates co-inhib...

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Literature Corpus work: b0677d5e-13d6-5323-a418-bd054f1791bf
DOI: 10.21203/rs.3.rs-133494/v1

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