Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunotherapies: The Blockade of Inhibitory Signals

1 Jan 2012

Abstract excerpt

T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptors such as CTLA-4, PD-1, and BTLA have recently drawn much attention as potential targets for immunotherapies. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23197939
DOI: 10.7150/ijbs.5273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunotherapies: The Blockade of Inhibitory SignalsPMID 23197939Read ↗

Co-Inhibitory Pathways and Their Importance in Immune RegulationSemantic proximity Read ↗

The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

Basic science for the clinician 55: CTLA-4.Semantic proximity Read ↗

Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapySemantic proximity Read ↗

The B7 family of immune-regulatory ligands.Semantic proximity Read ↗

Costimulatory and coinhibitory receptors in anti‐tumor immunitySemantic proximity Read ↗

Coinhibitory Pathways in Immunotherapy for CancerSemantic proximity Read ↗

Control of T Cell Function by Positive and Negative RegulatorsSemantic proximity Read ↗

Molecular Recognition of Paired Receptors in the Immune SystemSemantic proximity Read ↗

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activationSemantic proximity Read ↗

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targetsSemantic proximity Read ↗

Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.