Article

Integration of IL-2 and IL-4 Signals Coordinates Divergent Regulatory T cell Responses and Drives Therapeutic Efficacy

2020-04-14

Abstract excerpt

Cells exist within complex milieus of communicating factors, such as cytokines, that combine to generate context-specific responses, yet nearly all knowledge about the function of each cytokine and the signaling propagated downstream of their recognition is based upon the response to individual cytokines. Here, we found that regulatory T cells (Tregs) integrate concurrent signaling initiated by IL-2 and IL-4 to ge...

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Literature Corpus work: ae4db84a-73c5-5316-80d2-d91cdd772b57
DOI: 10.1101/2020.04.14.040485

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