Article

Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors

2023-04-27

Abstract excerpt

Adoptive T cell therapy aims to achieve lasting tumour clearance, requiring enhanced engraftment and survival of the immune cells. Cytokines are paramount modulators of T cell survival and proliferation. Cytokine receptors signal via ligand-induced dimerization, and this principle has been hijacked utilising non-native dimerization domains. A major limitation of current technologies resides in the absence of a mod...

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Literature Corpus work: 05c268c5-ca4f-56b9-ad87-80d80c0cc9d5
DOI: 10.1101/2023.04.24.538039

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