Article

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells

2024-02-23

Abstract excerpt

CD8+ T cells contribute to immune responses by producing cytokines when their T cell receptors (TCRs) recognise peptide antigens on major-histocompability-complex (pMHC) class I. However, excessive cytokine production can be harmful. For example, cytokine release syndrome (CRS) is a common toxicity observed in treatments that activate T cells, including chimeric antigen receptor (CAR)-T cell therapy. While engagem...

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Literature Corpus work: 8d3470d1-6812-5f5e-91c9-9c28d34d7f4d
DOI: 10.1101/2024.02.21.581341

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