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Article

Genome-wide investigation of synthetic rescue interactions in Alzheimer's disease implicates glial lipid and sterol metabolism.

Alzheimer's research & therapy - 11 Apr 2026

Yoo Jun Ki, Kim Ju Han

Abstract excerpt

BACKGROUND: Synthetic rescue (SR) interactions, where a disease-promoting alteration in one gene is compensated by a secondary alteration in another gene, remain largely unexplored in Alzheimer’s disease (AD). Here, we performed a genome-wide investigation of SR gene pairs that mitigate the genetic risk of AD. METHODS: Using whole exome sequencing (WES) data from the Alzheimer’s Disease Sequencing Project (ADSP)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41965838
DOI: 10.1186/s13195-026-02009-4
PMCID: PMC13262459

Genes

AKR1C4
APOE
DMC1
LPP
NR4A1
OR52H1
RBAK
SULT2A1
TREM2
ZNF510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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