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Changes in iPSC-astrocyte morphology reflect Alzheimer’s disease patient clinical markers

14 Dec 2024

Abstract excerpt

Human induced pluripotent stem cells (iPSCs) provide powerful cellular models of Alzheimer's disease (AD) and offer many advantages over non-human models, including the potential to reflect variation in individual-specific pathophysiology and clinical symptoms. Previous studies have demonstrated that iPSC-neurons from individuals with Alzheimer's disease (AD) reflect clinical markers, including β-amyloid (Aβ)...

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PMID: 39704342
DOI: 10.1093/stmcls/sxae085

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