Article

TACC3–ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation

2014-08-21

Abstract excerpt

The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto mitotic spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule-binding surface. Recent work indicates th...

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Literature Corpus work: dfd3173c-8679-5fcc-85e8-bcf6dbe05256
DOI: 10.1101/008359

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