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Article

XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation.

Nature communications - 29 Sept 2014

Mortuza Gulnahar B, Cavazza Tommaso, Garcia-Mayoral Maria Flor, Hermida Dario, Peset Isabel, Pedrero Juan G, Merino Nekane, Blanco Francisco J, Lyngsø Jeppe, Bruix Marta, Pedersen Jan Skov, Vernos Isabelle, Montoya Guillermo

Abstract excerpt

chTOG is a conserved microtubule polymerase that catalyses the addition of tubulin dimers to promote microtubule growth. chTOG interacts with TACC3, a member of the transforming acidic coiled-coil (TACC) family. Here we analyse their association using the Xenopus homologues, XTACC3 (TACC3) and XMAP215 (chTOG), dissecting the mechanism by which their interaction promotes microtubule elongation during spindle...

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Source

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Identifiers

PMID: 25262927
DOI: 10.1038/ncomms6072
PMCID: PMC4200520

Genes

TACC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation.PMID 25262927Read ↗

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