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Article

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.

The Journal of cell biology - 28 Jun 2010

Lin Chiou-Hong, Hu Chi-Kuo, Shih Hsiu-Ming

Abstract excerpt

Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part via phosphorylating human TACC3 on S558, which triggers TACC3 relocalization to mitotic spindles and stabilizes microtubules (MTs). In this study, we identified clathrin heavy chain (CHC) as an adaptor protein to recruit S558-phosphorylated TACC3 onto the spindle during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20566684
DOI: 10.1083/jcb.200911120
PMCID: PMC2894451

Genes

TACC3

Provenance

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Related research

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Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.PMID 20566684Read ↗

TACC3–ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylationSemantic proximity Read ↗

Oocyte Spindle Proteomics Analysis Leading to Rescue of Chromosome Congression Defects in Cloned EmbryosSemantic proximity Read ↗

Trimerisation is important for the function of clathrin at the mitotic spindleSemantic proximity Read ↗

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.Semantic proximity Read ↗

AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylationSemantic proximity Read ↗

Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.Semantic proximity Read ↗

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A ActivitySemantic proximity Read ↗

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.Semantic proximity Read ↗

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.Semantic proximity Read ↗

TACC3-TSC2 maintains nuclear envelope structure and controls cell divisionSemantic proximity Read ↗

Cdh1 controls the stability of TACC3.Semantic proximity Read ↗

The mechanism of acentrosomal spindle assembly in human oocytesSemantic proximity Read ↗

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