Article

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

2022-05-20

Abstract excerpt

Centrosome amplification (CA) is a hallmark of cancer that is strongly associated with highly aggressive disease and worse clinical outcome. However, there are no effective strategies targeting cancer cells with CA while sparing normal cells. Here, we identified Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) to be overexpressed in tumors with CA, and its high expression is associated with dramaticall...

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Literature Corpus work: b34d5a55-f828-5237-bb71-e02181f642c5
DOI: 10.1101/2022.05.18.492567

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