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Article

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.

The Journal of cell biology - 26 Sept 2005

Barros Teresa P, Kinoshita Kazuhisa, Hyman Anthony A, Raff Jordan W

Abstract excerpt

Centrosomes are the dominant sites of microtubule (MT) assembly during mitosis in animal cells, but it is unclear how this is achieved. Transforming acidic coiled coil (TACC) proteins stabilize MTs during mitosis by recruiting Minispindles (Msps)/XMAP215 proteins to centrosomes. TACC proteins can be phosphorylated in vitro by Aurora A kinases, but the significance of this remains unclear. We show that Drosophila...

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Identifiers

PMID: 16186253
DOI: 10.1083/jcb.200504097
PMCID: PMC2171528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.PMID 16186253Read ↗

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.Semantic proximity Read ↗

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.Semantic proximity Read ↗

Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1.Semantic proximity Read ↗

Xenopus TACC1 is a microtubule plus-end tracking protein that can regulate microtubule dynamics during embryonic development.Semantic proximity Read ↗

Centrosomes and cancer: lessons from a TACC.Semantic proximity Read ↗

Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability.Semantic proximity Read ↗

XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation.Semantic proximity Read ↗

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.Semantic proximity Read ↗

Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.Semantic proximity Read ↗

Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.Semantic proximity Read ↗

TACC3–ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylationSemantic proximity Read ↗

Aurora B regulates MCAK at the mitotic centromere.Semantic proximity Read ↗

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